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. 2011 Nov 29;31(3):667–678. doi: 10.1038/emboj.2011.422

Figure 2.

Figure 2

The OA receptor, SER-6, is required for the OA inhibition of aversive responses to 100% 1-octanol. (A–C) Aversive behaviour to 100% 1-octanol was assayed off food in wild-type, mutant and transgenic animals after incubation in exogenous OA (4 or 10 mM). Black bars, wild-type or null animals; grey bars, null animals expressing a transgene. Data are presented as a mean±s.e. and analysed by two-tailed Student's t-test. *P<0.001, significantly different from wild-type animals under identical test conditions; **P<0.001, significantly different from null mutant. (D) OA is the preferred ligand for SER-6. SER-6 was heterologously expressed in Xenopus oocytes and oocytes were exposed to DA, TA, OA and 5-HT (1 μM) for up to 30 s. (E) OA dose–response curve for oocytes expressing SER-6.