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. 2011 Nov 8;31(3):640–653. doi: 10.1038/emboj.2011.400

Figure 10.

Figure 10

Amphetamine locomotor sensitization after D1R or D2R MSN ablation in the DMS or DLS. (A, D, G, J) Topographic representation of the lesioned areas in D1-DTR+ (A, G) and A2A-DTR+ (D, J) DT-injected mice into the DMS (A, D) or the DLS (G, J). Colours represent percent of superimposed lesioned areas. (B, C, E, F, H, I, K, L) Locomotor activity in a 60-min open field after repeated d-amphetamine (3 mg/kg) administration in DMS D1-DTR (B, C) and A2A-DTR (E, F) or DLS D1-DTR (H, I) and A2A-DTR (K, L) DT-injected mice. Histograms represent ambulation following first and last d-amphetamine administration. Data are reported as mean±s.e.m. (n=10–17 per group). Statistical comparisons were made between DTR+ and respective DTR− control mice (dot chart) or between first and last amphetamine injection (histograms). *P<0.05, **P<0.01.