Table 1. Summary of the observed behaviours in each ablation model.
DMS ablation |
DLS ablation |
Entire striatum ablation |
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---|---|---|---|---|---|---|
D1 neurons | D2 neurons | D1 neurons | D2 neurons | D1 neurons | D2 neurons | |
Open field | ||||||
Total locomotion | ↓ | ↑ | ↔ | ↔ | ↓ | ↑ |
Habituation | ↔ | Inverted | ↔ | ↔ | ↔ | Absent |
Rotarod | ||||||
Learning curve | ↔ | Initial ↓ | ↓ | ↔ | ↓ | Initial ↓ |
Performance after learning | ND | ↔ | ↔ | ND | ↓ | ↔ |
Novel object | ||||||
Exploration of novel object | ↓ | ↑ | ↔ | ↔ | ND | ND |
Exploration of old object | ↔ | ↑ | ↔ | ↔ | ND | ND |
Object memory | ↔ | ↔ | ↔ | ↔ | ND | ND |
Haloperidol-induced catalepsy | ↔ | ↓ | ↔ | ↔ | ND | ND |
Amphetamine-induced locomotion | ||||||
Acute effect | ↓ | ↔ | ↔ | ↑ | ND | ND |
Sensitization | ↔ | ↓ | ↔ | ↔ | ND | ND |
ND, not determined. |