Figure 7.

Kinesin-mediated intracellular trafficking functions together with autophagy to facilitate necrotic cell death. Number of neuron corpses, at the L1 larval stage of development, per 100 animals carrying the neurotoxic mec-4(d) allele in genetic backgrounds deficient for both intracellular trafficking and autophagy. (A) Kinesin 1 heavy chain (UNC-116) deficiency. (B) Monomeric kinesin UNC-104 deficiency. In both cases, no significant synthetic protection of neurons is observed in LGG-1/LC3-depleted animals with impaired autophagy. Error bars denote s.e.m. values (n>250 for all populations examined; P>0.5, compared with single mutant control animals, unpaired t-test).