Table 3.
Change in “pain now” NPRS score from before topical anesthetic application on the day of treatment
| L.M.X.4 (n = 39) | Topicaine (n = 38) | Betacaine (n = 40) | |
|---|---|---|---|
| 25 min after patch application, mean ± SD | −2.2 ± 2.76 | −0.9 ± 3.19 | −1.9 ± 2.43 |
| 55 min after patch application, mean ± SD | −0.9 ± 3.72 | 0.6 ± 3.90 | −0.3 ± 3.08 |
| Within 5 min after patch removal, mean ± SD | −0.8 ± 3.29 | 0.1 ± 3.10 | −0.1 ± 2.48 |
| 25 min after patch removal, mean ± SD | −0.6 ± 3.23 | −0.4 ± 2.41 | −1.0 ± 2.56 |
| 55 min after patch removal, mean ± SD | −0.5 ± 3.55 | −0.7 ± 2.53 | −1.1 ± 2.93 |
| 85 min after patch removal, mean ± SD | −0.3 ± 3.48c | −0.8 ± 2.68 | −1.4 ± 2.96 |
| 155 min after patch removal, mean ± SD | −0.2 ± 3.59 | −1.2 ± 2.49 | −1.5 ± 2.80 |
| Patients reporting a ≥33% pain increase from baseline during the first 48 hours, n (%) | 28 (72) | 28 (74) | 30 (75) |
| P valuea | – | 0.832 | 0.747 |
| Patients using medication for treatment-related discomfort during days 0–5, n (%) | 20 (51) | 26 (68) | 20 (50) |
| P valueb | – | 0.195 | 0.922 |
a
Notes: P value was computed from a Cochran–Mantel–Haenszel test, adjusted for treatment duration, comparing the proportions between the L.M.X.4 group and the other two topical anesthetic groups;
b
P value was computed from a chi-squared test comparing the proportions between the L.M.X.4 group and the other two topical anesthetic groups;
c
38 patients only.
Abbreviation: SD, standard deviation.