Table 5.
Efficacy of NGX-4010
| L.M.X.4 | Topicaine | Betacaine | |
|---|---|---|---|
| NPRS scores | |||
| Baseline, LS mean ± SE | 5.6 ± 0.23 | 5.9 ± 0.23 | 5.4 ± 0.23 |
| Weeks 2–12, n | 39 | 38 | 40 |
| Actual (LS mean ± SE) | 3.9 ± 0.32 | 3.8 ± 0.33 | 4.0 ± 0.32 |
| Change from baseline (LS mean ± SE) | −1.7 ± 0.32 | −1.8 ± 0.33 | −1.6 ± 0.32 |
| Percentage change from baseline (LS mean ± SE) | −31.8 ± 5.61 | −34.3 ± 5.72 | −27.2 ± 5.56 |
| P valuea | – | 0.757 | 0.563 |
| Patients with ≥30% decrease from baseline to weeks 2–12, n (%) | 18 (46) | 19 (50) | 18 (45) |
| P valueb | – | 0.588 | 0.864 |
| Patients with ≥50% decrease from baseline to weeks 2–12, n (%) | 13 (33) | 14 (37) | 11 (28) |
| P valueb | – | 0.610 | 0.608 |
| PGIC | |||
| Week 12, n | 36 | 37 | 38 |
| Much improved (very much, much), n (%) | 14 (39) | 13 (35) | 16 (42) |
| Improved (very much, much, slightly), n (%) | 21 (58) | 24 (65) | 27 (71) |
Notes: P value was computed using ANCOVA to test for difference between the L.M.X.4 group and the other two topical anesthetic groups.
b
P value was computed using logistic regression to test for difference between the L.M.X.4 group and the other two topical anesthetic groups.
Abbreviations: ANCOVA, analysis of covariance; LS mean, least squares mean; NPRS, Numeric Pain Rating Scale; PGIC, Patient Global Impression of Change; SE, standard error.