Figure 2.

Distribution of HDL particles in groups treated with NER/S (2000/40 mg/day) combination therapy and atorvastatin monotherapy (40 mg/day) at baseline and week 12. The difference in HDL particle size distribution at week 12 between NER/S and atorvastatin after adjusting for HDL particle size at baseline is highly significant (P < 0.0001). Size ranges of HDL particle subclasses were large (8.8–13 nm), medium (8.2–8.8 nm), and small (7.3–8.2). The P value^a is from the Cochran–Mantel–Haenszel test and is shown for significant comparison in HDL particle size distribution between NER/S combination therapy and atorvastatin monotherapy.

Abbreviations: HDL, high-density lipoprotein; NER/S, extended-release niacinsimvastatin.