Table 3.
Biological implication |
Nonhistone proteins affected by acetylation |
|
---|---|---|
Upregulation | Downregulation | |
Protein stability | p53, p73, Smad7, c-Myc, Runx3, AR, H2A.z, E2F1, NF-E4, ER81, SREBP1a, HNF6, BACE1 |
GATA1, HIF-1α, pRb, SV40 T-Ag |
DNA binding | p53, SRY, STAT3, GATA transcription factors, E2F1, p50 (NF-κB), Erα, p65 (NF-κB), c-Myb, MyoD, HNF-4, AML1, BETA2, NF-E2, KLF13, TAL1/SCL, TAF(I)68, AP endonuclease |
YY1, HMG-A1, HMG-N2, p65 (NF-αB), DEK, KLF13, Fen-1 |
Transcriptional regulation |
Transcriptional activation: p53, HMG-A1, STAT3, AR, ERα (basal), GATA transcription factors, EKLF, MyoD, E2F1, p65 (NF-αB), GR, p73, PGC1α, MEF2D, GCMa, PLAG1, PLAGL2, Bcl-6, α-catenin, KLF5, Sp1, BETA2, Cart1, RIP140, TAF(I)68 |
Transcriptional inactivation ERα (ligand-bound), HIF-1α, STAT1, FoxO1, FoxO4, RIP140 |
Protein–protein interactions |
STAT3, AR, EKLF, importin A, STAT1, TFIIB, α-tubulin, actin, cortactin |
p65(RelA), Ku70, heat-shock protein 90 |
DNA repair | p53, E2F, TDF | NAIL2, FEN1, Pol b |
Protein localization | PCAF, SRY, CtBP2, POP-1, HNF-4, PCNA subnuclear WRN, PCNA |
c-Abl, p300, PAP |
mRNA stability | p21, Brm | Tyrosine hydrolase (Th), eNOS |
Enzymatic activity | p300, ATM | PTEN, HDAC1, Mdm2, ACS, Neil2, Polα |
Mitochondrial proteins | ACS, Sod1/2 | Profilin I, Thioredoxin |
Viral proteins | SV40 T-Ag | E1A, HIV Tat, S-HDAg, L-HDAg |
AR: Androgen receptor; EKLF: Erythroid Kruppel-like factor; ER: Estrogen receptor; GR: Glucocorticoid receptor; HMG: High-mobility group; NF-κB: Nuclear factor κB; SRY: Sex-determining region Y.