. Author manuscript; available in PMC: 2012 Feb 6.

Published in final edited form as: Expert Rev Anticancer Ther. 2010 Jun;10(6):935–954. doi: 10.1586/era.10.62

Table 3.

Biochemical and cellular activities regulated by acetylation.

Biological implication	Nonhistone proteins affected by acetylation
Biological implication	Upregulation	Downregulation
Protein stability	p53, p73, Smad7, c-Myc, Runx3, AR, H2A.z, E2F1, NF-E4, ER81, SREBP1a, HNF6, BACE1	GATA1, HIF-1α, pRb, SV40 T-Ag
DNA binding	p53, SRY, STAT3, GATA transcription factors, E2F1, p50 (NF-κB), Erα, p65 (NF-κB), c-Myb, MyoD, HNF-4, AML1, BETA2, NF-E2, KLF13, TAL1/SCL, TAF(I)68, AP endonuclease	YY1, HMG-A1, HMG-N2, p65 (NF-αB), DEK, KLF13, Fen-1
Transcriptional regulation	Transcriptional activation: p53, HMG-A1, STAT3, AR, ERα (basal), GATA transcription factors, EKLF, MyoD, E2F1, p65 (NF-αB), GR, p73, PGC1α, MEF2D, GCMa, PLAG1, PLAGL2, Bcl-6, α-catenin, KLF5, Sp1, BETA2, Cart1, RIP140, TAF(I)68	Transcriptional inactivation ERα (ligand-bound), HIF-1α, STAT1, FoxO1, FoxO4, RIP140
Protein–protein interactions	STAT3, AR, EKLF, importin A, STAT1, TFIIB, α-tubulin, actin, cortactin	p65(RelA), Ku70, heat-shock protein 90
DNA repair	p53, E2F, TDF	NAIL2, FEN1, Pol b
Protein localization	PCAF, SRY, CtBP2, POP-1, HNF-4, PCNA subnuclear WRN, PCNA	c-Abl, p300, PAP
mRNA stability	p21, Brm	Tyrosine hydrolase (Th), eNOS
Enzymatic activity	p300, ATM	PTEN, HDAC1, Mdm2, ACS, Neil2, Polα
Mitochondrial proteins	ACS, Sod1/2	Profilin I, Thioredoxin
Viral proteins	SV40 T-Ag	E1A, HIV Tat, S-HDAg, L-HDAg

AR: Androgen receptor; EKLF: Erythroid Kruppel-like factor; ER: Estrogen receptor; GR: Glucocorticoid receptor; HMG: High-mobility group; NF-κB: Nuclear factor κB; SRY: Sex-determining region Y.