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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Future Oncol. 2011 Dec;7(12):1415–1428. doi: 10.2217/fon.11.124

Table 2.

Histone deacetylase inhibitors modulate gene transcription in endothelial cells to inhibit tumor-driven angiogenesis.

Gene Function on
angiogenesis		 Target cell Direction of
modulation		 Ref.
Tie2 Promotes Endothelial ↓ [61]
Ang2 Promotes Endothelial ↓ [61]
Nrp1 Promotes Endothelial ↓ [62]
SEMA3 Suppresses Endothelial ↑ [62]
VEGFR1 Promotes Endothelial ↓ [62]
VEGFR2 Promotes Endothelial ↓ [62]
eNOS Promotes Endothelial ↓ [63]
VEGFD P Promotes Endothelial ↓ [64]