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Confirmation of hMLH1 methylation. DNA methylation in the selected samples was examined by methylation-specific PCR. All the 7 cancers (H1–H7) expressing the highest levels of hMLH1 contain an unmethylated hMLH1 gene. Cancers with the lowest hMLH1 mRNA were found to contain completely methylated (L1–L7), partially methylated (marked by “*”) or unmethylated (marked by “**”) promoters.
