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. 2011 Dec 2;4:82. doi: 10.1186/1755-8794-4-82

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Copyright ©2011 Park et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparison of methylation patterns in normal and cancerous tissue. (A) Average MES curve for normal (black) and cancerous (red) tissue in chromosome 19 (left). The average MES for CGIs, gene bodies, and repeats (right).(B) DNA methylation of gene annotated elements. Each element (upstream 1 kb, exon, intron, and downstream 1 kb) were partitioned into 20 bins and the average MES was obtained for each bin of all corresponding elements. (C) DNA methylation at transcript ends and coding region ends. The average MES was obtained in a sliding 50-bp window according to its distance from the transcript start (first) and end (second) for CGI-positive promoters as well as the transcript start (third) and end (fourth) for CGI-positive promoters. (D) DNA methylation of total 5' UTR exons (left) and 5' UTR coding exons (right).