Table 3.
Functional annotation clustering of genes with hypermethylated 5'CGIs
| Annotation Cluster 1 | Enrichment Score: 3.27 | Count | P_Value |
|---|---|---|---|
| GOTERM_BP_FAT | nucleosome assembly | 11 | 3.90E-04 |
| GOTERM_BP_FAT | chromatin assembly | 11 | 5.20E-04 |
| GOTERM_BP_FAT | protein-DNA complex assembly | 11 | 7.40E-04 |
| Annotation Cluster 2 | Enrichment Score: 2.92 | Count | P_Value |
| INTERPRO | Histone core | 8 | 6.80E-04 |
| SP_PIR_KEYWORDS | nucleosome core | 8 | 8.60E-04 |
| GOTERM_CC_FAT | nucleosome | 8 | 3.10E-03 |
| Annotation Cluster 3 | Enrichment Score: 2.16 | Count | P_Value |
| INTERPRO | Homeobox, conserved site | 17 | 5.10E-03 |
| INTERPRO | Homeobox | 17 | 5.70E-03 |
| SP_PIR_KEYWORDS | Homeobox | 17 | 5.80E-03 |
| INTERPRO | Homeodomain-related | 17 | 6.40E-03 |
| SMART | HOX | 17 | 1.40E-02 |
| Annotation Cluster 4 | Enrichment Score: 2.02 | Count | P_Value |
| PIR_SUPERFAMILY | brain-expressed X-linked protein | 3 | 9.10E-03 |
| PIR_SUPERFAMILY | PIRSF008633:BEX | 3 | 9.10E-03 |
| INTERPRO | Brain expressed X-linked like protein | 3 | 1.00E-02 |
| Annotation Cluster 5 | Enrichment Score: 1.97 | Count | P_Value |
| PIR_SUPERFAMILY | PIRSF002051:histone H3 | 3 | 9.10E-03 |
| INTERPRO | Histone H3 | 3 | 1.00E-02 |
| SMART | H3 | 3 | 1.30E-02 |
| Annotation Cluster 6 | Enrichment Score: 1.78 | Count | P_Value |
| UP_SEQ_FEATURE | domain:Helix-loop-helix motif | 10 | 1.20E-02 |
| INTERPRO | Basic helix-loop-helix dimerisation region bHLH | 10 | 1.40E-02 |
| SMART | HLH | 10 | 2.60E-02 |
| Annotation Cluster 7 | Enrichment Score: 1.77 | Count | P_Value |
| GOTERM_CC_FAT | focal adhesion | 9 | 1.30E-02 |
| GOTERM_CC_FAT | cell-substrate adherens junction | 9 | 1.60E-02 |
| GOTERM_CC_FAT | cell-substrate junction | 9 | 2.20E-02 |
| Annotation Cluster 8 | Enrichment Score: 1.55 | Count | P_Value |
| GOTERM_BP_FAT | regulation of B cell proliferation | 5 | 1.20E-02 |
| GOTERM_BP_FAT | positive regulation of B cell activation | 5 | 2.20E-02 |
| GOTERM_BP_FAT | regulation of B cell activation | 5 | 8.40E-02 |
| Annotation Cluster 9 | Enrichment Score: 1.55 | Count | P_Value |
| PIR_SUPERFAMILY | PIRSF500606:homeotic protein Hox D4 | 3 | 9.10E-03 |
| SP_PIR_KEYWORDS | embryo | 3 | 3.30E-02 |
| PIR_SUPERFAMILY | PIRSF002612:homeotic protein Hox A5/D4 | 3 | 3.70E-02 |
| INTERPRO | Homeobox protein, antennapedia type | 3 | 5.90E-02 |
| Annotation Cluster 10 | Enrichment Score: 1.38 | Count | P_Value |
| GOTERM_MF_FAT | substrate specific channel activity | 21 | 3.40E-02 |
| GOTERM_MF_FAT | channel activity | 21 | 4.60E-02 |
| GOTERM_MF_FAT | passive transmembrane transporter activity | 21 | 4.70E-02 |