Table 3.
Association of urinary PGE-M levels and colorectal adenoma risk, Tennessee Colorectal Polyp Study
| Study Group | PGE-M (quartile)
|
p for trend | |||
|---|---|---|---|---|---|
| Q1 (low) | Q2 | Q3 | Q4 | ||
| Polyp-Free Controls | |||||
| n | 90 | 89 | 90 | 89 | |
| Any Advanced Adenoma | |||||
| n | 26 | 51 | 76 | 69 | |
| OR (95% CI) a | 1.00 (reference) | 1.64 (0.90–2.95) | 2.42 (1.37–4.28) | 2.17 (1.20–3.92) | 0.006 |
| OR (95% CI) b | 1.00 (reference) | 1.56 (0.84–2.90) | 2.25 (1.23–4.09) | 1.84 (0.97–3.48) | 0.04 |
| Multiple Small Tubular Adenoma | |||||
| n | 16 | 36 | 44 | 52 | |
| OR (95% CI) a | 1.00 (reference) | 2.13 (1.02–4.44) | 2.13 (1.03–4.40) | 2.57 (1.24–5.34) | 0.03 |
| OR (95% CI) b | 1.00 (reference) | 2.59 (1.20–5.60) | 2.31 (1.07–5.00) | 2.88 (1.32–6.24) | 0.03 |
| Single Small Tubular Adenoma | |||||
| n | 66 | 80 | 73 | 79 | |
| OR (95% CI) a | 1.00 (reference) | 1.14 (0.72–1.82) | 0.99 (0.61–1.61) | 1.11 (0.67–1.82) | 0.87 |
| OR (95% CI) b | 1.00 (reference) | 1.16 (0.72–1.86) | 0.93 (0.56–1.53) | 1.04 (0.62–1.74) | 0.88 |
| Advanced or Multiple Adenoma | |||||
| n | 42 | 87 | 120 | 121 | |
| OR (95% CI) a | 1.00 (reference) | 1.84 (1.11–3.05) | 2.32 (1.41–3.81) | 2.34 (1.41–3.87) | 0.001 |
| OR (95% CI) b | 1.00 (reference) | 1.95 (1.15–3.30) | 2.31 (1.37–3.89) | 2.19 (1.28–3.76) | 0.008 |
a
Adjusted for age, gender, race, educational attainment, and study site
b
Additionally adjusted for cigarette smoking, alcohol consumption, BMI, red meat intake, and NSAID use