Table 4.
Associations of urinary PGE-M levels and advanced or multiple small tubular colorectal adenoma risk stratified by NSAID use, smoking status, and gender, Tennessee Colorectal Polyp Study
| PGE-M (quartile)
|
p for trend | p for interaction | ||||
|---|---|---|---|---|---|---|
| Q1 (low) | Q2 | Q3 | Q4 | |||
| Males | ||||||
| Case/Controls | 24/34 | 59/55 | 97/68 | 95/76 | ||
| OR (95% CI) a | 1.00 (reference) | 1.52 (0.75–3.09) | 1.96 (1.01–3.83) | 1.58 (0.81–3.10) | 0.24 | |
| Females | 0.96 | |||||
| Case/Controls | 18/56 | 28/34 | 23/22 | 26/13 | ||
| OR (95% CI) a | 1.00 (reference) | 2.71 (1.14–6.42) | 2.33 (0.87–6.23) | 5.40 (1.78–16.41) | 0.006 | |
| Never or Former NSAID Users | ||||||
| Case/Controls | 23/46 | 42/41 | 50/39 | 62/39 | ||
| OR (95% CI) a | 1.00 (reference) | 1.91 (0.90–4.04) | 2.19 (1.01–4.75) | 2.29 (1.03–5.09) | 0.06 | |
| Current NSAID Users | 0.80 | |||||
| Case/Controls | 15/43 | 34/47 | 53/50 | 46/49 | ||
| OR (95% CI) a | 1.00 (reference) | 2.36 (1.06–5.28) | 2.96 (1.38–6.36) | 2.51 (1.14–5.54) | 0.04 | |
| Never Smokers | ||||||
| Case/Controls | 15/55 | 32/50 | 30/42 | 30/33 | ||
| OR (95% CI) a | 1.00 (reference) | 1.90 (0.86–4.20) | 1.91 (0.83–4.38) | 2.44 (1.01–5.89) | 0.03 | |
| Former/Current Smokers | 0.88 | |||||
| Case/Controls | 23/34 | 45/38 | 73/47 | 80/56 | ||
| OR (95% CI) a | 1.00 (reference) | 1.98 (0.94–4.16) | 2.74 (1.36–5.54) | 2.09 (1.04–4.20) | 0.06 | |
a
Adjusted for age, race, educational attainment, study site, alcohol consumption, BMI, red meat intake, and cigarette smoking or gender or NSAID use