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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Trends Cell Biol. 2011 Nov 28;22(2):116–124. doi: 10.1016/j.tcb.2011.10.003

Figure 3. Model integrating membrane curvature produced by the PLA2 activity of PAFAH Ib α1 and α2 with Lis1-mediated dynein transport along microtubules.

Figure 3

PAFAHIB initiates outward membrane curvature to generate a membrane tubule, which can be pulled/extended along microtubules (MT) by Lis1 and Ndel interactions with dynein. Dynein may be able to carry the membrane tubule towards the minus end of microtubules, facilitating the convergence of the Golgi stack and positioning at the microtubule organizing center (MTOC, minus end of the microtubules).

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