TABLE 1.
| Phospholipase Name | Official Gene Symbol | Aliases | PLA2 Group No. (REF) | C'some location; Protein m.w. | Features | Inhibitors |
|---|---|---|---|---|---|---|
| cPLA2α | PLA2G4A | cPLA2 GIVA cPLA2 |
IVA | 1: 85 kD | -Ca2+-dependent membrane binding -C2 domains -Ser/Asp dyad |
Pyrrolidine ONO-RS-082 MAFP AACOCF3 |
| PAFAH Ib α1 α2 β |
PAFAHIb2 PAFAHIb3 PAFAHIb1 |
Catalytic subunit 2 Catalytic subunit 3 Lis1; Regulatory subunit 1 |
VIIIA VIIIB |
11; 30 kD 19; 20 kD 17; 45 kD |
-Ca2+-independent -Specificity for PAF -Ser/His/Asp tTriad -GXSXG consensus |
BEL ONO-RS-082 |
| iPLA2-β | PLA2G6 | iPLA2-B, PNPLA9, L-iPLA2 (long transcript) GVIA-2 iPLA2 | VIA-2 | 22; 85 kD | -Ca2+-independent -ATP binding stabilizes activity -Multiple splice variants -S519/GXSXG consensus |
BEL ONO-RS-082 AACOCF3 MAFP |
| iPLA1γ | DDHD2 | KIAA0725p, Phospholipase DDHD2, DDHD domain-containing protein 2 | NA | 8; 81 kD | -GXSXG consensus -S351 active site -Preference for PA |
? |