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. Author manuscript; available in PMC: 2013 Feb 15.
Published in final edited form as: J Immunol. 2012 Jan 13;188(4):1726–1733. doi: 10.4049/jimmunol.1102879

FIGURE 2.

FIGURE 2

CNS-4 is required for human IFN-γ production. A, Transgenic CD4+ cells were cultured under Th1 and Th2 polarizing conditions for three days. Human IFN-γ (left) or mouse IFN-γ (right) concentrations were determined from cultures. B, Day five CD4+ Th1 cultures were restimulated with anti-CD3, or IL-12 and IL-18, or IL-12 and IL-2. Human and mouse IFN-γ concentrations were determined by ELISA. Results are representative of independent replicates. Error bars are standard deviations. * P < 0.05.