Figure 5. STAT1 is necessary for early MV control but is not required for MV clearance from CNS neurons.

(A) Brains were removed at 11 dpi from NSE-CD46⁺ and NSE-CD46⁺/STAT1-KO mice and assessed by qRT-PCR for levels of IFNγ message (n= 8). (B) MV RNA in the brains of MV-infected mice. Animals were infected IC with MV (2×10⁴ PFU), and brains were harvested at 4, 11, and 40 dpi. RNA was extracted and subjected to qRT-PCR for MV-N. (n= 6–10 mice per time point). Statistical analysis was applied via unpaired t-test (*p<0.04 versus NSE-CD46⁺ mice on the same dpi; **p<0.003 versus NSE-CD46⁺ mice on the same dpi).