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. Author manuscript; available in PMC: 2013 Feb 3.
Published in final edited form as: Biochem Biophys Res Commun. 2012 Jan 3;418(1):56–61. doi: 10.1016/j.bbrc.2011.12.127

Fig. 3. RRD-251 inhibits nicotine mediated induction of E-selectin and monocyte binding.

Fig. 3

(A) Nicotine stimulated E2F1 binding on E-selectin promoter was suppressed by RRD-251 as seen in a ChIP assay. (B) Nicotine stimulated expression of E-selectin was significantly suppressed by RRD-251 in dose dependent manner. (C) U937 monocytic cells adhered on nicotine stimulated HAECs, which was significantly blocked by RRD-251 (p < 0.05).