Table 1.
Characteristics of randomized controlled trials.
| authors | Year | country | number of reference | institutions of the study | Conversion rate (%) | Study size (n) | follow-up period (months) | Randomization | Double Blinding | Withdrawals and dropouts | Jadad's score | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LC | OC | |||||||||||
| Braga et al. | 2010 | Italy | 10 | single center | 5.2(7/134) | 134 | 134 | 73 months (median) | 2 | 2 | 1 | 5 |
| CLASICC trial | 2010, 2007, 2005 | UK | 6, 7, 13, 21 | multicenter (27) | 25(61/246) | 526 | 268 | 56.3 months (median) | 2 | 2 | 1 | 5 |
| COLOR trial | 2009, 2005 | Sweden, Netherlands, Spain, Italy, France, UK, Germany |
14, 15 | multicenter (29) | 19(102/534) | 534 | 542 | 53 months (median) | 2 | 2 | 1 | 5 |
| COST trial | 2004 | USA and Canada | 16, 18 | multicenter (48) | 21(90/435) | 435 | 428 | 7 years (median) | 2 | 2 | 1 | 5 |
| Curet et al. | 2000 | USA | 17 | single center | 28(7/25) | 25 | 18 | 4.9 years (mean) | 2 | 2 | 1 | 5 |
| ALCCaS trial (Hewett et al.) | 2008 | Australia and New Zealand | 24 | multicenter (31) | 14.6(43/294) | 294 | 298 | unknown | 2 | 0 | 1 | 3 |
| Kaiser et al. | 2004 | USA | 22 | single center | 46.4(13/28) | 28 | 20 | 35 months (median) | 2 | 0 | 1 | 3 |
| Barcelona trial (Lacy et al.) | 2008 | Spain | 8, 9 | single center | 11(12/111) | 111 | 108 | 95 months (median) | 2 | 2 | 1 | 5 |
| Liang at al. | 2006 | Taiwan | 19 | single center | 3(4/135) | 135 | 134 | 40 months (median) | 2 | 2 | 1 | 5 |
| Mirza et al. | 2008 | UK | 20 | single center | 17 (19/113) concluding rectal cancer | 116 | 117 | 48 months (median) | 1 | 0 | 0 | 1 |
| Pascual et al. | 2011 | Spain | 23 | single center | 12(7/60) | 60 | 60 | 41 months (median) | 2 | 2 | 1 | 5 |
| Winslow et al | 2002 | USA | 25 | single center | 15(7/46) | 46 | 43 | 30.1 months (mean) | 2 | 0 | 1 | 3 |
UK: United Kingdom, US: United States of America