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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Eur J Med Chem. 2011 Dec 13;48:164–173. doi: 10.1016/j.ejmech.2011.12.010

Scheme 1.

Scheme 1

Synthetic routes to bisnitriles 1a – 3a, 7a, 11a – 13a, 15a and bisamidines 1 – 3, 7, 11 – 13, 15 with atom numbering; i: K2CO3, N-methyl-2-pyrrolidone; ii: DMSO; iii: 1) HCl/EtOH, 2) NH3/EtOH.