Table 1.

Anti-Pnemocystis Activity (IC₅₀), A549 and L2 toxicity of compounds 1 – 13, 15 – 20.

Name	Chemical structure	IC50 (µg/ml) ± SD for P. carinii	IC50 (µM)	Activity ranking	A549 Toxicity IC50 (µg/ml)	L2 Toxicity IC50 (µg/ml)
1		0.82 ± 0.44	1.73	Marked	>100	>100
2		2.10 ± 1.24	3.41	Moderate	>100	>100
3		45.21 ± 16.9	6.26	Slight	>100	>100
4		1.02 ± 0.51	1.99	Moderate	>100	47.1
5		0.47 ± 0.09	1.11	Marked	>100	36.9
6		0.96 ± 0.32	2.13	Marked	>100	>100
7		2.00 ± 1.65	4.21	Moderate	>100	>100
8		7.66 ± 1.67	12.99	Moderate	>100	>100
9		1.68 ± 0.37	3.00	Moderate	>100	17.8
10		0.52 ± 0.04	1.18	Marked	>100	>100
11		0.81 ± 0.12	1.33	Marked	>100	>100
12		1.80 ± 0.76	2.66	Moderate	>100	>100
13		3.13 ± 0.99	4.40	Moderate	>100	>100
15		2.59 ± 0.83	3.71	Moderate	>100	>100
16		3.24 ± 0.88	4.16	Moderate	>100	>100
17		1.53 ± 0.90	2.99	Moderate	>100	>100
18		1.85 ± 0.01	3.58	Moderate	>100	>100
19		7.40 ± 0.22	14.33	Moderate	>100	>100
20		4.90 ± 1.20	9.15	Moderate	>100	>100