Table 2.
Summary of sequelae risk after intrauterine and neonatal insults
| Neonates assessed (n) | Sequelae (n; %) |
Type of sequelae (n; % of total with impairment) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Cognition, general developmental delay, or learning difficulties | Cerebral palsy | Deaf or hearing loss | Impaired vision or blind | Gross motor and coordination* | Epilepsy | Behavioural problems | |||
| Sepsis (5 studies) | 2442 | 977 (40%) | 720 (74%) | 353 (36%) | 97 (10%) | 317 (32%) | 5 (1%) | .. | .. |
| Meningitis (11 studies) | 501 | 209 (42%) | 209 (100%) | 43 (21%) | 25 (12%) | 84 (40%) | 10 (5%) | 24 (11%) | 3 (1%) |
| Hypoxic ischaemic encephalopathy (27 studies) | 2708 | 1002 (37%) | 453 (45%) | 291 (29%) | 95 (9%) | 258 (26%) | 167 (17%) | 122 (12%) | 15 (1%) |
| Preterm birth (47 studies) | 6558 | 2006 (31%) | 1209 (60%) | 539 (27%) | 148 (7%) | 224 (11%) | 202 (10%) | 20 (1%) | 25 (1%) |
| Jaundice (20 studies) | 7212 | 1311 (18%) | 985 (75%) | 190 (14%) | 146 (11%) | .. | 36 (3%) | 40 (3%) | 57 (4%) |
| Tetanus (4 studies) | 109 | 28 (26%) | 28 (100%) | 1 (4%) | .. | .. | 4 (14%) | .. | 6 (21%) |
| Cytomegalovirus (17 studies) | 918 | 377 (41%) | 250 (66%) | 23 (6%) | 251 (67%) | 13 (3%) | 60 (16%) | 23 (6%) | 7 (2%) |
| Herpes (9 studies) | 311 | 116 (37%) | 109 (94%) | 32 (28%) | 2 (2%) | 55 (47%) | 34 (29%) | 27 (23%) | 2 (2%) |
| Rubella (6 studies) | 890 | 720 (81%) | 42 (6%) | .. | 576 (80%) | 191 (27%) | 44 (6%) | .. | 2 (<1%) |
| Toxoplasmosis (5 studies) | 512 | 105 (21%) | 27 (26%) | .. | .. | 86 (82%) | 1 (1%) | 12 (11%) | .. |
| Syphilis (0 studies) | .. | .. | .. | .. | .. | .. | .. | .. | .. |
| Overall | 22 161 | 6851 (31%) | 4032 (59%) | 1472 (21%) | 1340 (20%) | 1228 (18%) | 563 (8%) | 268 (4%) | 117 (2%) |
Impairment by sequelae type greater than 100% because of overlap.
*
Cerebral palsy was not defined and classified but motor and coordination impairments were reported.