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. 2011 Oct 3;40(3):941–955. doi: 10.1093/nar/gkr763

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — (a) Schematic representation of the MB strategy for the switch-on detection of prokaryotic ssDNA binding protein via the target-induced conversion of the MB hairpin into an ss conformation (27). (b) Schematic representation of MB strategy for the switch-on detection of prokaryotic CAP via the target-promoted association of the half-site duplexes (30). (c) Schematic representation of the unimolecular beacon strategy for the switch-off detection of thrombin via the target-induced formation of the closed state (31).