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(a) Schematic representation of the molecular aptamer beacon strategy for the switch-on detection of thrombin via the target-induced conversion of the MB hairpin into the G-quadruplex aptamer (45). (b) Schematic representation of the molecular aptamer beacon strategy for the switch-on (FRET) or switch-off (quenching) detection of thrombin via the target-induced conversion of the random coil into the G-quadruplex aptamer (51).
