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. 2011 Oct 3;40(3):941–955. doi: 10.1093/nar/gkr763

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — (a) Schematic representation of the structure-switching aptamer strategy for the switch-on detection of thrombin via the target-induced dissociation of the duplex structure (52). (b) Schematic representation of molecular aptamer beacon design for the switch-on (FRET) or switch-off (quenching) detection of thrombin based on the target-induced co-association of two distinct aptamer recognizing distinct epitopes (53). (c) Schematic representation of aptamer beacon design for the excimer-based detection of PDGF via the target-induced hybridization of the terminal arms (54). (d) Schematic representation of the polyethylene glycol-linked aptamer beacon strategy for the switch-on detection of thrombin via the target-induced dissociation of the duplex conformation (58).