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. 2011 Nov 29;40(3):e21. doi: 10.1093/nar/gkr908

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Abnormal karyotype of clones that retain a wild-type allele. (A) Structure of Myo10 locus analyzed in (B–D). (B) PCR genotyping as in Figure 2D. All double-resistant subclones retain the wild-type allele. (C) All these subclones have a single-transposon integration site (top) but contain both pre- (In: insertion) and post-Cre (Del: deleted) forms of the transposon (bottom). (D) Spectral karyotype showing tetraploidy in a double-resistant subclone. (E) An example of a less severe aberration—only chromosome 6, which bears the insertion at the Grid2 locus, is present in excess. Left, FISH showing three copies of chromosome 6 with (white arrows) and without (yellow arrow) transposon insertions (red dots). Right, spectral karyotype.