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Calculation of the rate of LOH at three loci on chromosome 11 by fluctuation analysis
| Locus | Mb | Cultures | Median FIAUR/culture | Plating efficiency | Mean cells/culture | LOH events/culture (mh)a | LOH rate (10−5 events/cell/division) |
|---|---|---|---|---|---|---|---|
| D8 | 21 | 19 | 1 | 0.35 | 753 000 | 7.53 | 0.99 |
| Gdf9 | 54 | 14 | 3.5 | 0.38 | 762 000 | 18.56 | 2.5 |
| F8 | 96 | 18 | 6.5 | 0.27 | 739 000 | 40.95 | 5.5 |
aSee ref. (34) for details of calculation. FIAUR, FIAU-resistant colonies.
