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. Author manuscript; available in PMC: 2013 Feb 3.
Published in final edited form as: FEBS Lett. 2011 Dec 28;586(3):235–241. doi: 10.1016/j.febslet.2011.12.016

Figure 1. Apoptosis and CL oxidation induced by AcD in MEC.

Figure 1

A - Apoptosis induced by AcD in MEC. (a) Caspase 3/7 activation and (b) PS externalization in MEC exposed to AcD (100 ng/ml). Data are means ± S.E., n=10, *p<0.05 vs control. B - AcD-induced oxidation of CL in MEC. (a) Typical negative mode ESI-MS spectrum of CL obtained from MEC, LC/MS quantitative assessment of oxidizable (b) and oxidized (c) CL molecular species. CL oxidation products with 1–4 oxygens in each oxidized CL molecular species were detected and shown on inserts. (d) Base peak chromatogram of CL molecular species with m/z 1464. A higher intensity of the peak with m/z 1464 corresponding to oxygenated CL molecular species ((C18:2)3(C18:2-OH), retention time 12.2 min) was detected in AcD treated MEC. Data are means ± S.E., n=7, *p<0.03 vs control.