Skip to main content
. 2011 Dec 17;3(12):1169–1177. doi: 10.18632/aging.100408

Figure 1. Ip injection of Oxt suppresses food intake and activates neurons in the hypothalamus and brain stem in standard diet fed mice.

Figure 1

(A) Food intake after ip injection of Oxt. White, gray and black bars indicate saline (n = 5), 200 μg/kg dose of Oxt (n = 5) and 400 μg/kg dose of Oxt (n = 5), respectively. (B-E) C-Fos expression in the PVN (B), ARC (C), LC (D), and the region including NTS, DMX and AP (E) after saline (each left panel) or 400 μg/kg dose of Oxt (each right panel) injection. cc: central canal. (F) Number of c-Fos immunoreactive neurons in the feeding-related areas of the hypothalamus and brain stem after injection of 400 μg/kg dose of Oxt (filled bars) or saline (open bars). n = 5 for Oxt and for control. *p < 0.05, **p < 0.01.