Table 1.

P16 expression and HPV status of lung carcinomas including squamous cell carcinomas in patients with prior squamous cell carcinomas of the head and neck

Tumor type	P16 IHC (%)	HPV ISH (%)
Small cell carcinoma	3/3 (100)	0/3 (0)
Non-small cell carcinoma, NOS	1/12 (8)	0/12 (0)
Adenocarcinoma	15/74 (20)	0/74 (0)
Large cell/pleomorphic carcinoma	4/11 (36)	0/11 (0)
Squamous cell carcinoma
No prior squamous cell carcinoma	14/66 (21)	0/66 (0)
Prior head and neck squamous cell carcinoma*	17/54 (31)	11/54 (20)
oropharynx	15/28 (54)	11/28 (39)
oral cavity	1/7 (14)	0/7 (0)
larynx	1/20 (5)	0/20 (0)
hypopharynx	0/1 (0)	0/1 (0)

IHC, immunohistochemistry; HPV, human papillomavirus; ISH, in situ hybridization; NOS, not otherwise specified

^*two patients had primary SqCCs involving the oropharynx and a non-oropharyngeal site