Table 1. Prevalence of endocrinopathies in 30 homozygous beta-thalassaemic patients*.
| Parameter | Hypogonadism | Hypopara thyroidism |
Hypo Thyroidism |
Diabetes Mellitus | No Endocrinopathy |
||
|---|---|---|---|---|---|---|---|
| Hypo Gonadotrophic |
Normo Gonadotrophic |
||||||
| No. (M/F) | 15 (8/7) | 7 (1/6) | 3 (1/2) | 1 (0/1)** | 8 (6/2) | 8 (6/2) | |
| Prevalence | 50% | 23.3% | 10.0% | 3.3% | 26.7% | 26.7% | |
| Age at Diagnosis (years) |
Mean ± SD | 17.5±4.96 | 18.57±2.76 | 17.0±3.6 | 15 | 17.6±2.1 | - |
| Median | 16.0 | 19.0 | 16 | - | 17.5 | - | |
| Range | 13-32 | 15-22 | 14-21 | - | 15-21 | - | |
| Age at Study (years) |
Mean ± SD | 21.0±3.48 | 21.57±3.82 | 22.3±4.1 | 16 | 21.5±2.39 | 20.0±2.6 |
| Median | 21.0 | 23.0 | 19.0 | - | 21.0 | 20.0 | |
| Range | 18-32 | 17-28 | 19-27 | - | 19-27 | 17-24 | |
| Ferritin (µg/L) | Mean ± SD | 5794±3413 | 7726±2620 | 5348±2038 | 4950 | 6445±3979 | 5647±3663 |
| Median | 6030 | 7424 | 5744 | - | 6257 | 5014 | |
| Range | 568-4318 | 4318-12473 | 3933-7951 | - | 1576-12540 | 865-11809 | |
| Significance of difference in Ferritin (P)*** | 0.838 | 0.191 | 0.812 | - | 0.618 | - | |
*: no patient had hypocortisolism
**: only one patient had hypothyroidism, statistical data are not presented
***: significance of difference in ferritin in comparison with patients without endocrinopathy