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Western blot analysis of activated PDGFR-β (p-PDGFR-β) levels in the renal cortex. (A) Three days ureteral obstruction resulted in an increased activation of PDGFR-β tyrosine kinase. (B) Inhibitory effects were only obtained with daily intraperitoneal injections of 50 mg/kg sunitinib malate.
Abbreviations: PDGFR, platelet-derived growth factor receptors; UUO, unilateral ureteral obstruction.
