Figure 7.

Model summarizing potential modes of action of the identified export inhibitors. Compounds may bind to CRM1 and, in an allosterical or competitive manner, affect its NES-binding domain, thereby preventing the assembly of a functional export complex. Alternatively, the compounds may directly interact with the specific NES itself or target putative cofactors required for the assembly of protein specific export complexes. Compounds displaying such a bioactivity profile would be of therapeutic interest.