Figure 5.

PLZF-deficient mice cannot induce protection from acoustic trauma with restraint stress. Plotted are ABR thresholds as a function of frequency for wild-type mice (PLZF (+/+); left) and PLZF-deficient (+/−) mice (right) measured 7 d after a 2 h exposure to a 100 dB SPL broadband (8–16 kHz) sound. In wild-type mice, restraint stress administered just before the noise exposure prevented most of the noise-induced hearing loss (p < 0.001 by ANOVA), while PLZF-deficient mice were not able to generate protection with restraint stress (p > 0.05 by ANOVA). Means ± SE with 4–7 mice in each group.