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. 2012 Mar 1;35(3):335–344. doi: 10.5665/sleep.1690

Figure 5.

Figure 5

Genotype-dependent difference in initial slow-wave activity (SWA) is independent of EEG location. Mean absolute SWA (0.75-4.5 Hz) values (± SEM) in fronto-central (FC), centro-parietal (CP), and parieto-occipital (PO) EEG derivations are plotted for the first 4 NREM sleep episodes in baseline and recovery nights. Gray dots: Val/Val allele carriers (n = 11). Black dots: Val/Met allele carriers (n = 11). Data were analyzed with 4-way, mixed-model ANOVA with the factors genotype (Val/Val, Val/Met), condition (baseline, recovery), NREM sleep episode (1-4) and derivation (FC, CP, PO). Val/Val genotype subjects exhibited higher SWA than Val/Met genotype subjects (genotype: F1,122 = 27.8, P < 0.0001). No interactions involving the factor genotype were found (main effects: condition: F1,209 = 39.0, P < 0.0001; NREM sleep episode: F3,257 = 403.2, P < 0.0001; derivation: F2,377 = 45.7, P < 0.0001). Except for the FC derivation in the recovery night, post hoc Tukey HSD tests indicated a difference between the genotypes in all derivation in NREM sleep episode 1 (P-values).