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Different Her dimers preferentially bind specific E boxes. (A,B) EMSA of Her1 (A) and Her12 (B) homodimers binding to the five consensus (E1-E5) and seven non-consensus (e1-e7) E boxes upstream of her7. The Her1 homodimer binds to E2, E3, E4, E5, e3 and e5, whereas the Her12 homodimer binds to E1, E2, E3, E4, E5, e2, e3, e4, e5, e6 and e7.
