Figure 4.

Mean (± standard error [SE]) fluid intake, urine output, and net fluid balance over each 24-h period of the study in lethal toxin (LT)–challenged canines randomized to no therapy (control), conventional hemodynamic support alone (Hemo), or in combination with protective antigen–directed monoclonal antibody (Hemo + mAb). The format for this figure is similar to the previous ones. Shaded areas represent time over which LT was infused, and number of animals contributing to data at each time point may be determined from survival plots in Figure 2. All P values were based on linear mixed models, and P ≤ .05 were considered significant.