Figure 5.

A, Mean (± standard error [SE]) amounts of norepinephrine (NE) usage averaged over each 24-h period required to maintain mean arterial blood pressure (MAP) ≥80 mmHg in the 2 groups of LT-challenged animals randomized to this treatment—Hemo and Hemo + mAb. Inset shows corresponding changes form baseline in MAP in the 2 groups, similar to Figure 3A. The Hemo group required a significantly higher amount of NE to maintain similar MAP levels compared with the Hemo + mAb group over the second half of the study (P values for comparisons below figure). B, Because MAP and NE usage are interdependent, we present a combined score, termed the shock index (SI), by calculating the difference between normalized values of MAP and NE usage. Values progressively greater than zero denote a less severely ill state, whereas values less than zero denote more severe illness. The Hemo + mAb group did significantly better than the Hemo group over the second half of the study period (P ≤ .008). All P values were based on linear mixed models, and P ≤ .05 were considered significant.