Figure 7.

Mean (± standard error [SE]) changes from baseline over the study period in mean arterial blood pressure (MAP), heart rate (HR), central venous pressure (CVP), left ventricular ejection fraction (LVEF), and hemoglobin (Hb) in canines challenged with a 24-h infusion of lethal toxin (shaded area) and treated with either protective antigen–directed monoclonal antibody (PA-mAb; mAb in the figure) alone or a combination of hemodynamic support and PA-mAb (Hemo + mAb). Data for the combination therapy group were combined across all PA-mAb administration times [0 h (n = 5), 9 h (n = 3), or 12 h (n = 4)]. Animals treated with PA-mAb alone are divided into 2 groups on the basis of early administration of treatment [0 h (n = 5)] or later administration [9 h and 12 h (n = 7)]. The format for this figure is similar to Figure 3. All P values were based on linear mixed models, and P ≤ .05 was considered significant.