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Structure of the Itk SH2 domain-swapped dimer (a) compared with the (b) Grb2 SH2 and (c) Nck SH2 domain-swapped dimers. In (a), (b) and (c) the extended hinge loops that deviate from the closed monomer structures to yield the domain-swapped form are labeled: the EF loop in Itk and Grb2 and the DE loop in Nck. The CD loops and BG loops of Itk SH2 (a) and the Grb2 SH2 domain (b) are labeled to illustrate the differences in the dimer interface in these otherwise related structures.
