Table 1.
Baseline characteristics of participants by MTHFR C677T or MTR A2756G polymorphism1
| MTHFR C677T | MTR A2756G | |||||||
|---|---|---|---|---|---|---|---|---|
| All | CC | CT | TT | P | AA | AG/GG | P | |
| N | 445 | 114 | 221 | 110 | 365 | 80 | ||
| Sex(Male), no.(%) | 191(42.9) | 51(44.7) | 91(41.2) | 49(44.5) | 0.761 | 155(42.5) | 36(45.0) | 0.678 |
| Age, yrs | 57.0(9.8) | 57.0(9.5) | 56.4(9.6) | 58.2(10.4) | 0.284 | 57.0(9.8) | 57.0(9.9) | 0.971 |
| BMI, kg/m2 | 25.7(3.5) | 25.5(3.9) | 25.8(3.3) | 25.7(3.3) | 0.758 | 25.8(3.5) | 25.2(3.5) | 0.137 |
| SBP, mmHg | 154.0(11.2) | 154.0(11.5) | 153.8(11.4) | 154.5(10.5) | 0.863 | 153.8(11.2) | 155.1(11.2) | 0.324 |
| DBP, mmHg | 93.0(8.3) | 92.4(8.5) | 93.4(7.8) | 92.8(9.0) | 0.530 | 93.3(8.0) | 91.4(9.4) | 0.052 |
| FPG, mmol/L | 5.5(1.3) | 5.5(1.5) | 5.4(1.2) | 5.7(1.2) | 0.312 | 5.5(1.3) | 5.5(1.2) | 0.865 |
| TC, mmol/L | 5.0(1.1) | 5.0(1.4) | 4.9(1.0) | 5.1(1.0) | 0.555 | 5.0(1.1) | 4.9(1.1) | 0.259 |
| HDL-C, mmol/L | 1.3(0.4) | 1.3(0.4) | 1.3(0.4) | 1.3(0.4) | 0.479 | 1.3(0.4) | 1.3(0.3) | 0.542 |
| TG, mmol/L | 1.7(1.2) | 1.7(1.0) | 1.8(1.2) | 1.7(1.5) | 0.970 | 1.8(1.3) | 1.6(0.8) | 0.252 |
| Creatinine, μmol/L | 69.5(17.5) | 68.0(17.5) | 69.2(17.3) | 71.9(17.9) | 0.233 | 69.2(17.9) | 71.3(15.6) | 0.334 |
| Folate, nmol/L2 | 12.6(1.5)[12.3] | 13.7(1.4)[13.4] | 13.0(1.5)[12.6] | 11.0(1.4)[10.8] * | < 0.001 | 12.8(1.5)[12.5] | 11.9(1.5)[11.6] | 0.107 |
| Homocysteine, μmol/L2 | 13.2(1.6)[12.1] | 11.2(1.4)[11.1] | 12.0(1.4)[11.5] | 18.8 (1.8)[17.5] * | < 0.001 | 13.1(1.6)[12.1] | 13.3(1.6)[12.6] | 0.794 |
BMI = body mass index, SBP = systolic blood pressure, DBP = diastolic blood pressure, FPG = fasting plasma glucose,
TC = total cholesterol, HDL-C = high-density lipoprotein cholesterol, TG = triglyceride;
1Means (SD); 2geometric mean (anti-log SD), median in brackets; * Significantly different from the CT or CC genotype, P < 0.001.