Table 3.
Enzymes | Inhibitors | Ref |
---|---|---|
HMG-CoA synthase | Hymeglusin | [84] |
HMG-CoA reductase | Statins | [6] |
Mevalonate kinase | Farnesyl thiodiphosphate | [85] |
Mevalonate diphosphate decarboxylase | 6-fluoro-Mevalonate 5-diphosphate | [86] |
Farnesyl diphosphate synthase | Alendronate, Ibandronate, Pamidronate |
[87,88] |
Geranylgeranyl diphosphate synthase | Digeranyl bisphosphonate | [89] |
Farnesyltransferase | Manumycin, Gliotoxin | [36,37,40] |