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. 2011 Dec 28;10:243. doi: 10.1186/1476-511X-10-243

Table 3.

List of inhibitors against enzymes of the mevalonate pathway.

Enzymes Inhibitors Ref
HMG-CoA synthase Hymeglusin [84]
HMG-CoA reductase Statins [6]
Mevalonate kinase Farnesyl thiodiphosphate [85]
Mevalonate diphosphate decarboxylase 6-fluoro-Mevalonate 5-diphosphate [86]
Farnesyl diphosphate synthase Alendronate, Ibandronate,
Pamidronate
[87,88]
Geranylgeranyl diphosphate synthase Digeranyl bisphosphonate [89]
Farnesyltransferase Manumycin, Gliotoxin [36,37,40]