Table 1.
Characteristics of pooled studies*
| No | Study name | Study year and location | Number screened | Age (y) | Screening tests | Follow-up procedure | Histology or cytology location and review |
| 1 | SPOCCS I | 1999; Xiangyuan County, Shanxi Province | 1997 | 35–45 | HC2 (self, physician), fluorescence test, LBC, VIA, colposcopy | All women received four-quadrant biopsies and ECC under colposcopy. | CICAMS; Blinded International Review |
| 2 | SPOCCS II | 2001–2002; Xiangyuan and Yangcheng Counties, Shanxi Province | 8497 | 35–50 | HC2 (self, physician), LBC, VIA, AFB | Positive VIA, self-test or physician-test for high-risk HPV, or an abnormal AFB, or a positive Pap test (ASC–US or worse): four-quadrant biopsies and ECC. | CICAMS |
| 3 | SPOCCS III-(1) | 2006; Xiangyuan County, Shanxi Province | 884 | 16–54 | HC2 (self, physician), LBC, VIA | (1) Positive VIA or positive self-collected HC2: colposcopy and directed biopsy, ECC if necessary; (2) positive physician-collected HC2 or ASC-H and LSIL+ on LBC: colposcopy and four-quadrant biopsies, ECC if necessary. | CICAMS; Blinded International Review (only histology) |
| 4 | SPOCCS III-(2) | 2006; Xinmi, Henan Province | 879 | 16–54 | HC2 (self, physician), LBC, VIA | Same as SPOCCS III-(1) | CICAMS; Blinded International Review (only histology) |
| 5 | SPOCCS III-(3) | 2006; Yutian County, Xinjiang Uygur Autonomous Region | 883 | 16–54 | HC2 (self, physician), LBC, VIA | Same as SPOCCS III-(1) | CICAMS; Blinded International Review (Histology); People's Hospital of Xinjiang Uygur Autonomous Region; Blinded CICAMS Review (Cytology) |
| Total | 13 140 |
*
AFB = Ampersand's fluorescent bio-molecular markers; ASC-H = atypical squamous cells—cannot exclude high-grade squamous intraepithelial lesion; ASC-US = atypical squamous cell of undetermined significance; CICAMS = Cancer Institute of the Chinese Academy of Medical Sciences; ECC = endocervical curettage; HC2 = Hybrid Capture 2; HPV = human papillomavirus; LBC = liquid-based cytology; LSIL+ = low-grade squamous intraepithelial lesion or more severe; SPOCCS = Shanxi Province Cervical Cancer Screening Study; VIA = visual inspection with acetic acid.