Table 4.
Uncorrected and corrected HC2 accuracy of Self-HPV, Physician-HPV, LBC and VIA for CIN2+ and CIN3+ (HPV DNA positivity: RLU/CO ≥ 1 pg/mL)*
| Screening methods | CIN2+ |
CIN3+ |
||
| Sensitivity, %, (95% CI) | Specificity, %, (95% CI) | Sensitivity, %, (95% CI) | Specificity, %, (95% CI) | |
| Self-HPV | ||||
| Uncorrected | 86.2 (82.9 to 89.1) | 80.7 (75.6 to 85.8) | 86.1 (81.4 to 90.0) | 79.5 (74.1 to 84.8) |
| Corrected | 85.0 (81.6 to 88.0) | 80.8 (80.1 to 81.4) | 85.8 (81.1 to 89.7) | 79.5 (78.8 to 80.2) |
| Difference | 1.2 | −0.1 | 0.3 | 0.0 |
| Physician-HPV | ||||
| Uncorrected | 97.0 (95.2 to 98.3) | 82.7 (78.4 to 87.0) | 97.8 (95.3 to 99.2) | 81.3 (76.7 to 85.8) |
| Corrected | 96.1 (94.1 to 97.6) | 82.5 (81.8 to 83.2) | 97.8 (95.3 to 99.2) | 81.1 (80.4 to 81.7) |
| Difference | 0.9 | 0.2 | 0.0 | 0.2 |
| LBC | ||||
| Uncorrected | 80.7 (77.0 to 84.0) | 94.0 (92.2 to 95.8) | 89.0 (84.7 to 92.5) | 92.8 (90.6 to 94.9) |
| Corrected | 80.0 (75.8 to 83.0) | 93.9 (93.4 to 94.3) | 88.8 (84.3 to 92.2) | 92.7 (92.2 to 93.1) |
| Difference | 0.7 | 0.1 | 0.2 | 0.1 |
| VIA | ||||
| Uncorrected | 50.3 (40.9 to 59.7) | 87.4 (79.5 to 95.4) | 55.7 (45.1 to 66.3) | 86.9 (78.9 to 94.8) |
| Corrected | 49.6 (45.2 to 54.0) | 87.5 (86.9 to 88.0) | 55.6 (49.6 to 61.7) | 86.9 (86.3 to 87.5) |
| Difference | 0.7 | −0.1 | 0.1 | 0.0 |
*
CI = confidence interval; CIN2+ = cervical intraepithelial neoplasia grade 2 or more severe; CIN3+ = cervical intraepithelial neoplasia grade 3 or more severe; LBC = liquid-based cytology; HC2 = Hybrid Capture 2; HPV = human papillomavirus; RLU/CO = relative light units per cutoff; VIA = visual inspection with acetic acid.