Table 3. Summary of results for the top-ranked SNP (ranked by pp) in each gene in European-ancestry samples for the major subtypes of non-Hodgkin lymphoma (SNP: odds ratio for additive model).
| DLBCL (n = 148) | FL (n = 165) | MZL/MALT (N = 55) | MCL (n = 40) | All B-cell (n = 523) | All T-cell (n = 45) | |
| BAX | rs4645900: 0.62 | rs4645900: 0.73 | rs704243: 1.34 | rs704243: 1.66 | rs4645900: 0.66 | rs11667229: 0.73 |
| BCL2 | rs4987873: 0.48 | rs1026825: 1.35 | rs1564483: 1.85 | rs7226979: 1.37 | rs4987852: 1.44 | rs1801018: 0.57 |
| BCL6 | rs1474326: 1.30 | BCL6_x10(3083)_A/T: 1.72 | rs1474326: 0.86 | rs2229362: 0.50 | rs3733017: 1.34 | rs1523474: 1.23 |
| BCL10 | rs12134420: 0.91 | rs4949928: 1.25 | rs4949927: 1.24 | rs4949927: 1.63 | rs4949928: 1.17 | rs12134420: 1.19 |
| BCL2L11 | rs3761704: 1.25 | rs10204044: 0.87 | rs17041883:0.29* | rs17041868: 0.46 | rs10204044: 0.89 | rs17041868: 0.54 |
| BBC3 | rs45474992: 0.54 | rs45474992: 0.68 | rs884171: 0.90 | rs45474992: 0.65 | rs45474992: 0.66 | rs884171: 0.73 |
| BECN1 | rs10512488: 1.36* | rs10512488: 0.93 | rs10512488: 1.38 | rs10512488: 1.52 | rs10512488: 1.13 | rs10512488: 1.16 |
| BMI1 | BMI1_UPSTR(-809)_C/T: 1.55 | BMI1_UPSTR(-809)_C/T: 1.04 | BMI1_UPSTR(-809)_C/T: 1.23 | BMI1_UPSTR(-809)_C/T: 0.53 | BMI1_UPSTR(-809)_C/T: 1.27 | rs985000: 0.49 |
| FAS | rs9658761: 1.34 | rs2147420: 0.81 | rs983751: 0.62 | rs2147420: 0.69 | rs978522: 1.19 | rs9658761: 1.61 |
| MCL1 | rs6655975: 1.40 | rs6655975: 0.77 | rs35392872: 0.47 | rs35392872: 0.59 | rs35661734: 1.82 | rs35661734: 2.63 |
| MDM2 | rs1695144: 0.45 | rs769412: 0.68 | rs3730536: 1.14 | rs1695147: 1.41 | rs769412: 0.85 | rs937283: 1.45 |
| PMAIP1 | rs1041978: 1.22 | rs1041978: 1.53 | rs9957673: 0.67 | rs1041978: 1.84 | rs1041978: 1.35 | rs1041978: 1.42 |
| RFWD2 | rs11587785: 1.27 | rs12738115: 0.63 | rs12738115: 0.63 | rs6676805: 2.05* | RFWD2_UPSTR(-184)_C/G: 0.70 | 11587785: 2.37 |
| SKP2 | rs3804439: 0.82 | rs2362973: 1.2 | rs:17279275: 0.63 | rs:17279275: 0.61 | rs4440390: 1.16 | rs10071838: 0.63 |
| MIR15A | rs9535416: 0.81 | rs9535416: 1.05 | rs9535416: 0.71 | rs2476391: 0.33 | rs9535416: 0.91 | rs2476391: 1.11 |
| MIR1792 | rs17642969: 0.89 | rs17642969: 0.98 | rs17642969: 0.74 | rs17642969: 0.85 | rs17642969: 1.03 | rs17642969: 0.41* |
| MIR155 | rs2829803: 0.87 | rs928883: 1.35 | rs928883: 2.80* ∧ | rs2829803: 0.78 | rs928883: 1.30 ( | rs2829803: 1.61 |
All analyses are done against 547 European-ancestry controls.
*: pp<0.05,
∧
: pf<0.05. All p-values and number of samples in each category are listed in Table S6.
DLBCL: Diffuse Large B-Cell Lymphoma, FL: Follicular Lymphoma, MZ/MALT: Marginal Zone lymphoma/Mucosa-Associated Lymphoma Tissue lymphoma, MCL: Mantle Cell lymphoma.