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. 2012 Feb 7;7(2):e30280. doi: 10.1371/journal.pone.0030280

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Murai et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Effect of IL-18 on IL-4 secreting splenocytes ELISPOTS. (B) T cell differentiation protocol used in Panels 3C–E and Fig. 4. (C, D and E) Effect of IL-18 or IL-4 on Th2 differentiation of naïve CD4+ T-cells isolated from WT mice (C), IL-4^−/− mice (D) and WT and STAT6^−/− mice (E). n = 5−7 per group.