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. 2012 Feb 7;7(2):e29434. doi: 10.1371/journal.pone.0029434

Table 2. Evaluation of antibacterial and cytotoxicity activity of propargyl-linked antifolates.

Cmpd #	MICMRSA^a	MICMRSA^b+FCS	MICS.pyogenes	MICS. pyogenes+FCS^c	IC₅₀MCF-10(µM)	IC₅₀ HepG2(µM)	Selectivity^d MRSA	SelectivityS. pyogenes
1	5.76 (16)	ND	0.097 (0.25)	ND	47	ND	3	188
2	0.71 (2)	ND	0.024 (0.064)	ND	55	ND	28	859
7	0.18 (1)	ND	0.006 (0.016)	ND	67	ND	67	4,187
8	0.66 (2)	5.2 (16)	0.66 (2)	2.6 (8)	32	ND	16	16
9	0.18 (0.5)	1.4 (4)	0.18 (0.5)	0.72 (2)	199	ND	398	398
10	0.72 (2)	11.4 (32)	0.18 (0.5)	5.7 (16)	38	94	19	76
11	0.74 (2)	11.9 (32)	0.74 (2)	6 (16)	54	77	27	27
24	0.04 (0.125)	0.09 (0.25)	0.04 (0.125)	0.09 (0.25)	220	233	1,760	1,760
25	0.09 (0.5)	ND	0.012 (0.032)	ND	85	171	170	2,656
26	0.02 (0.064)	0.09 (0.25)	0.04 (0.125)	0.09 (0.25)	217	199	3,391	1,736
27	0.04 (0.125)	0.09 (0.25)	0.04 (0.125)	0.09 (0.25)	409	465	3,272	3,272
28	0.08 (0.25)	0.16 (0.5)	0.04 (0.125)	0.09 (0.25)	475	>500	1,900	3,800
31	1.5 (4)	2.94 (8)	2.94 (8)	2.94 (8)	462	494	116	58
36	0.041 (0.125)	ND	0.08 (0.25)	ND	>500	>500	>4,000	>2,000
37	0.16 (0.5)	0.16 (0.5)	0.16 (0.5)	0.16 (0.5)	>500	ND	>1,000	>1,000
TMP	0.14 (0.5)	0.14 (0.5)	0.58 (2)	0.58 (2)	ND	ND	ND	ND

^a

MIC values for MRSA and S. pyogenes are reported in µg/mL (µM).

^b

MIC values for MRSA in the presence of 10% fetal calf serum (FCS) in µg/mL (µM).

^c

MIC values for S. pyogenes in the presence of 10% FCS in µg/mL (µM).

^d

Selectivity values are calculated as IC₅₀ (MCF10)/MIC (pathogen), both values in µM. ND: not determined.