Table 3.
Bayesian pharmacokinetics parameters (all subjects). CL is clearance. Vdss is volume of distribution at steady state. Beta is the terminal slope of the log concentration versus time profile. T½ Beta is the elimination half-life.
| Free Fraction | CL (mL/min/kg) |
CL mL/min/m2) |
Vdss (L/kg) |
Beta (hr−1) |
T½ Beta (hr) |
|
|---|---|---|---|---|---|---|
| Overall | ||||||
| N | 61 | 63 | 63 | 63 | 63 | 63 |
| Range | 0.07–0.48 | 0.3–7.75 | 6.50–147.17 | 0.49–3.40 | 0.017–0.118 | 5.9–42.0 |
| Mean ± s.d. | 0.10 ± 0.05 | 1.2 ± 0.93 | 33.33 ± 19.33 | 1.48 ± 0.54 | 0.048 ± 0.020 | 16.8 ± 7.1 |
| Median | 0.09 | 1.08 | 29.00 | 1.37 | 0.046 | 15.1 |
| 3 Month to < 3 Years | ||||||
| N | 17 | 18 | 18 | 18 | 18 | 18 |
| Range | 0.07–0.48 | 0.63–7.75 | 12.83–147.17 | 0.67–3.40 | 0.024–0.118 | 5.9–28.4 |
| Mean ± s.d. | 0.11 ± 0.10 | 1.57 ± 1.62 | 32.83 ± 30.17 | 1.62 ± 0.59 | 0.053 ± 0.027 | 15.8 ± 6.5 |
| 3 to < 13 Years | ||||||
| N | 28 | 29 | 29 | 29 | 29 | 29 |
| Range | 0.07–0.17 | 0.30–1.82 | 6.50–69.17 | 0.49–3.00 | 0.017–0.092 | 7.5–40.6 |
| Mean ± s.d. | 0.10 ± 0.02 | 1.12 ± 0.40 | 31.83 ± 13.83 | 1.50 ± 0.61 | 0.048 ± 0.017 | 16.9 ± 7.4 |
| 13 to < 18 Years | ||||||
| N | 16 | 16 | 16 | 16 | 16 | 16 |
| Range | 0.07–0.15 | 0.43–1.58 | 16.33–60.00 | 1.00–1.54 | 0.017–0.084 | 8.2–42.0 |
| Mean ± s.d. | 0.09 ± 0.02 | 0.95 ± 0.32 | 36.67 ± 12.00 | 1.27 ± 0.17 | 0.044 ± 0.016 | 17.8 ± 7.7 |